Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.

Loading Pathway...

Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Myosin light chain kinase, smooth muscle Muscarinic acetylcholine receptor M3 Myosin LC-P Myosin light chain 3 Calmodulin-1 Serine/threonine- protein phosphatase PP1-beta catalytic subunit Calmodulin-1 Inositol 1,4,5-trisphosphate Cevimeline Ca+ Ca+ Ca+ Cevimeline Phosphatidylinositol 4,5-bisphosphate Calcium Ca+ Diacylglycerol Muscle Contraction Muscle Relaxation Magnesium Calcium Manganese Myosin Sarcoplasmic Reticulum Increased calcium binds readily to calmodulin to activate myosin light chain kinase Activation of myosin light chain kinase leads to high concentration of myosin LC-P which causes contractions of the muscles There is an overall increase in calcium levels in the cytosol caused by the activation of the Gq signaling cascade Cytosol Salivary Gland Smooth Muscle Cell Cevimeline is an agonist of the Muscarinic acetylcholine receptor M3 Actin Actin and myosin bind bringing the filaments together causing muscle contraction Cevimeline is administered as an oral tablet
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 MYLK CHRM3 MYL3 MYL3 CALM1 PPP1CB CALM1 Inositol 1,4,5- trisphosphate Cevimeline Calcium Calcium Calcium Cevimeline Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Muscle Contraction Muscle Relaxation