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Alpha-1A
adrenergic
receptor
Beta-1
adrenergic
receptor
Beta-2
adrenergic
receptor
Amine oxidase
[flavin-
containing] A
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Aromatic-L-
amino-acid
decarboxylase
Dopamine beta-
hydroxylase
Tyrosine
3-monooxygenase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Catechol O-
methyltransferase
FAD
Norepinephrine
Phenelzine
Norepinephrine
Norepinephrine
Norepinephrine
Phenelzine
Phenelzine
Phenelzine
L-Dopa
Dopamine
CO
2
Ascorbic acid
O
2
Dehydroascorbic acid
H
2
O
H
2
O
O
2
3,4-Dihydroxymandelaldehyde
H
2
O
2
NH
3
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
NAD
H
2
O
3,4-Dihydroxymandelic acid
NADH
H
+
S-Adenosylmethionine
Vanillylmandelic acid
S-Adenosylhomocysteine
Magnesium
Gq signaling
cascade
Gs signaling
cascade
Pyridoxal
5'-phosphate
Fe2+
Pyrroloquinoline
quinone
Copper
Post synaptic neuron
Norepinephrine is
synthesized from tyrosine
and stored in presynaptic
vesicles.
Synapse
Cytosol
Presynaptic Neuron
Cytosol
Postsynaptic Neuron
Diffusion
Blood-Brain Barrier
Phenelzine is transported in
the neurons by the
noradenaline reuptake
transporter.
Phenelzine inhibits the
amine oxidase A and B. This
results in the decrease of
the metabolism of
norepinephrine.
The inhibition of this
enzyme will increase the
concentration in
norepinephrine in the
cytosol of the presynaptic
neuron.
Since depression is caused
by low level of free
serotonin and/or
norepinephrine, the
increasing in free
norepinephrine results in
the relief of depressive
symptoms.
Mood Improvement
Norepinephrine activates
post synaptic adrenergic
receptors which are
responsible for mood
improvements.
ADRA1A
ADRB1
ADRB2
MAOA
SLC18A2
SLC6A2
SLC18A2
SLC6A2
DDC
DBH
TH
ALDH3A1
COMT
Norepinephrine
Phenelzine
Norepinephrine
Norepinephrine
Norepinephrine
Phenelzine
Phenelzine
Phenelzine
L-Dopa
Dopamine
Carbon dioxide
Ascorbic acid
Oxygen
Dehydroascorbic
acid
Water
Water
Oxygen
3,4-
Dihydroxymandelaldehyde
Hydrogen
peroxide
Ammonia
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
NAD
Water
3,4-
Dihydroxymandelic
acid
NADH
Hydrogen Ion
S-
Adenosylmethionine
Vanillylmandelic
acid
S-
Adenosylhomocysteine
Gq signaling
cascade
Gs signaling
cascade