Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
Alpha-1A
adrenergic
receptor
Beta-1
adrenergic
receptor
Beta-2
adrenergic
receptor
Amine oxidase
[flavin-
containing] A
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Synaptic
vesicular amine
transporter
Sodium-
dependent
noradrenaline
transporter
Aromatic-L-
amino-acid
decarboxylase
Dopamine beta-
hydroxylase
Tyrosine
3-monooxygenase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Catechol O-
methyltransferase
Norepinephrine
Minaprine
Norepinephrine
Norepinephrine
Norepinephrine
Minaprine
Minaprine
Minaprine
L-Dopa
Dopamine
CO
2
Ascorbic acid
O
2
Dehydroascorbic acid
H
2
O
H
2
O
O
2
3,4-Dihydroxymandelaldehyde
H
2
O
2
NH
3
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
NAD
H
2
O
3,4-Dihydroxymandelic acid
NADH
H
+
S-Adenosylmethionine
Vanillylmandelic acid
S-Adenosylhomocysteine
Magnesium
Gq signaling
cascade
Gs signaling
cascade
FAD
Pyridoxal
5'-phosphate
Fe2+
Pyrroloquinoline
quinone
Copper
Norepinephrine is
synthesized from tyrosine
and stored in presynaptic
vesicles.
Synapse
Cytosol
Presynaptic Neuron
Cytosol
Postsynaptic Neuron
Diffusion
Blood-Brain Barrier
Minaprine is transported in
the neurons by the
noradenaline reuptake
transporter.
Minaprine inhibits the amine
oxidase A. This results in
the decrease of the
metabolism of
norepinephrine.
The inhibition of this
enzyme will increase the
concentration in
norepinephrine in the
cytosol of the presynaptic
neuron.
Since depression is caused
by low level of free
serotonin and/or
norepinephrine, the
increasing in free
norepinephrine results in
the relief of depressive
symptoms.
Mood Improvement
Norepinephrine activates
post synaptic adrenergic
receptors which are
responsible for mood
improvements.
ADRA1A
ADRB1
ADRB2
MAOA
SLC18A2
SLC6A2
SLC18A2
SLC6A2
DDC
DBH
TH
ALDH3A1
COMT
Norepinephrine
Minaprine
Norepinephrine
Norepinephrine
Norepinephrine
Minaprine
Minaprine
Minaprine
L-Dopa
Dopamine
Carbon dioxide
Ascorbic acid
Oxygen
Dehydroascorbic
acid
Water
Water
Oxygen
3,4-
Dihydroxymandelaldehyde
Hydrogen
peroxide
Ammonia
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
NAD
Water
3,4-
Dihydroxymandelic
acid
NADH
Hydrogen Ion
S-
Adenosylmethionine
Vanillylmandelic
acid
S-
Adenosylhomocysteine
Gq signaling
cascade
Gs signaling
cascade