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Alpha-1A adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Amine oxidase [flavin- containing] A Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Tyrosine 3-monooxygenase Aldehyde dehydrogenase, dimeric NADP-preferring Catechol O- methyltransferase Norepinephrine Moclobemide Norepinephrine Norepinephrine Norepinephrine Moclobemide Moclobemide Moclobemide L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O H2O O2 3,4-Dihydroxymandelaldehyde H2O2 NH3 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O NAD H2O 3,4-Dihydroxymandelic acid NADH H+ S-Adenosylmethionine Vanillylmandelic acid S-Adenosylhomocysteine Magnesium Gq signaling cascade Gs signaling cascade FAD Pyridoxal 5'-phosphate Fe2+ Pyrroloquinoline quinone Copper Norepinephrine is synthesized from tyrosine and stored in presynaptic vesicles. Synapse Cytosol Presynaptic Neuron Cytosol Postsynaptic Neuron Diffusion Blood-Brain Barrier Moclobemide is transported in the neurons by the noradenaline reuptake transporter. Moclobemide inhibits the amine oxidase A and B. This results in the decrease of the metabolism of norepinephrine. The inhibition of this enzyme will increase the concentration in norepinephrine in the cytosol of the presynaptic neuron. Since depression is caused by low level of free serotonin and/or norepinephrine, the increasing in free norepinephrine results in the relief of depressive symptoms. Mood Improvement Norepinephrine activates post synaptic adrenergic receptors which are responsible for mood improvements.
ADRA1A ADRB1 ADRB2 MAOA SLC18A2 SLC6A2 SLC18A2 SLC6A2 DDC DBH TH ALDH3A1 COMT Norepinephrine Moclobemide Norepinephrine Norepinephrine Norepinephrine Moclobemide Moclobemide Moclobemide L-Dopa Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water Water Oxygen 3,4- Dihydroxymandelaldehyde Hydrogen peroxide Ammonia L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water NAD Water 3,4- Dihydroxymandelic acid NADH Hydrogen Ion S- Adenosylmethionine Vanillylmandelic acid S- Adenosylhomocysteine Gq signaling cascade Gs signaling cascade