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Pathway Description
Demecarium Action Pathway (new)
Homo sapiens
Drug Action Pathway
Created: 2023-08-15
Last Updated: 2023-11-27
Demecarium is a cholinesterase inhibitor used in the treatment of glaucoma, acting as an indirect parasympathomimetic agent by increasing acetylcholine levels in the synaptic cleft. The mechanism of action is demecarium the drug acts on acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine stimulating muscarinic receptors that act on g-coupled protein receptors and initiating a downstream cascade of effects. The parasympathetic effect leads the pupil to constrict and stimulate the outflow of aqueous humor reducing intraocular pressure. It is a long-acting cholinesterase and very potent, due to this should only be used in patients with open-angle glaucoma.
References
Demecarium Pathway (new) References
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Pubmed: 8430939
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Pubmed: 15164053
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Pubmed: 9030575
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Pubmed: 9880589
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Pubmed: 10766861
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Pubmed: 10762541
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Pubmed: 9254841
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Pubmed: 1385409
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Pubmed: 7916667
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Pubmed: 3443095
Bonner TI, Young AC, Brann MR, Buckley NJ: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron. 1988 Jul;1(5):403-10. doi: 10.1016/0896-6273(88)90190-0.
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Pubmed: 8825633
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