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Nicotinic Acetylcholine Receptor Nicotinic Acetylcholine Receptor Voltage- dependent L-type calcium channel subunit alpha-1C Myosin light chain kinase Acetylcholinesterase Myosin LC-P Myosin light chain 3 N-type calcium channel Vesicular acetylcholine transporter High affinity choline transporter 1 Choline O- acetyltransferase Calmodulin-1 Myosin light chain phosphatase Ca+ Acetylcholine Na+ Distigmine Ca+ Choline Choline Na+ Ca+ Ca+ Distigmine Distigmine Acetyl-CoA Choline CoA H2O Acetic acid Manganese Ca+ Calmodulin-1 Acetylcholine Acetylcholine Muscle Contraction Muscle Relaxation Magnesium Presynaptic Neuron Motor End Plate 2. An action potential arrives at the nerve terminal and stimulates the opening of the calcium channel, causing an influx of calcium ions 1. Acetylcholine is synthesized and stored in synaptic vesicles at the nerve terminal 3. Calcium ions stimulates the release of neurotransmitter acetylcholine into the synaptic cleft via exocytosis 4. Acetylcholine in the synaptic cleft activates nicotinic receptors on the post-synaptic membrane. The activated nicotinic receptor stimulates sodium ion influx, depolarizing the cell 6. Acetylcholine is broken down by acetylcholinesterase into choline and acetyl-coa 7. Choline is taken back up into the nerve terminal and recycled to create more acetylcholine Distigmine has an affinity and binds agonistically to acetylcholine nicotinic and muscarinic receptors, stimulating muscle contraction for treatment of underactive destrusor muscle Vesicle Distigmine is administered orally and diffuses into the bloodstream and travels to its target within the brain Sacroplasmic Reticulum 5. Depolarization causes a release of calcium from the sarcoplasmic reticulum. Calcium binds to calmodulin that in turn activates myosin light chain kinase. Once phosphorylated starts initiating muscle contraction Neuromuscular Junction Distigmine inhibits acetylcholinesterase, preventing acetylcholine breakdown
Unknown Unknown CACNA1C MYLK2 ACHE MYL3 MYL3 CACNB1 SLC18A3 SLC5A7 CHAT CALM1 PPP1CB Calcium Acetylcholine Sodium Distigmine Calcium Choline Choline Sodium Calcium Calcium Distigmine Distigmine Acetyl-CoA Choline Coenzyme A Water Acetic acid Calcium CALM1 Acetylcholine Acetylcholine Muscle Contraction Muscle Relaxation
CACNA1C MYLK2 ACHE MYL3 MYL3 CACNB1 SLC18A3 SLC5A7 CHAT CALM1 PPP1CB Ca+ ACh Na+ Disti Ca+ Choline Choline Na+ Ca+ Ca+ Disti Disti Ac-CoA Choline CoA H2O Acoh Mn2+ Ca+ CALM1 ACh ACh Mus Con Mus Rel Mg2+ Presynaptic Neuron Motor End Plate 2. An action potential arrives at the nerve terminal and stimulates the opening of the calcium channel, causing an influx of calcium ions 1. Acetylcholine is synthesized and stored in synaptic vesicles at the nerve terminal 3. Calcium ions stimulates the release of neurotransmitter acetylcholine into the synaptic cleft via exocytosis 4. Acetylcholine in the synaptic cleft activates nicotinic receptors on the post-synaptic membrane. The activated nicotinic receptor stimulates sodium ion influx, depolarizing the cell 6. Acetylcholine is broken down by acetylcholinesterase into choline and acetyl-coa 7. Choline is taken back up into the nerve terminal and recycled to create more acetylcholine Distigmine has an affinity and binds agonistically to acetylcholine nicotinic and muscarinic receptors, stimulating muscle contraction for treatment of underactive destrusor muscle Vesicle Distigmine is administered orally and diffuses into the bloodstream and travels to its target within the brain Sacroplasmic Reticulum 5. Depolarization causes a release of calcium from the sarcoplasmic reticulum. Calcium binds to calmodulin that in turn activates myosin light chain kinase. Once phosphorylated starts initiating muscle contraction Neuromuscular Junction Distigmine inhibits acetylcholinesterase, preventing acetylcholine breakdown
CACNA1C MYLK2 ACHE MYL3 MYL3 CACNB1 SLC18A3 SLC5A7 CHAT CALM1 PPP1CB Ca2+ ACh Na+ Disti Ca2+ Choline Choline Na+ Ca2+ Ca2+ Disti Disti Ac-CoA Choline CoA H2O Acoh Ca2+ CALM1 ACh ACh Mus Con Mus Rel