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Amine oxidase [flavin- containing] B Alpha-2A adrenergic receptor Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Synaptic vesicular amine transporter Sodium- dependent noradrenaline transporter Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Tyrosine 3-monooxygenase Aldehyde dehydrogenase, dimeric NADP-preferring Catechol O- methyltransferase Pargyline Norepinephrine Norepinephrine Norepinephrine Norepinephrine Pargyline Pargyline Pargyline L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O 3,4-Dihydroxymandelaldehyde NAD H2O 3,4-Dihydroxymandelic acid NADH H+ S-Adenosylmethionine Vanillylmandelic acid S-Adenosylhomocysteine H2O O2 NH3 H2O2 FAD Magnesium Gi/o signaling cascade Pyridoxal 5'-phosphate Fe2+ Pyrroloquinoline quinone Copper Post synaptic neuron Norepinephrine is synthesized from tyrosine and stored in presynaptic vesicles. Synapse Cytosol Presynaptic Neuron Cytosol Postsynaptic Neuron Diffusion Blood-Brain Barrier Pargyline is transported in the neurons by the noradenaline reuptake transporter. Pargylinee inhibits the amine oxidase B. This results in the decrease of the metabolism of norepinephrine. The inhibition of this enzyme will increase the concentration in norepinephrine in the cytosol of the presynaptic neuron. Lower blood pressure Norepinephrine activates postsynaptic adrenergic receptors alpha-2 which are responsible for lowering the blood pressure in the sympathetic tone (in the local and regional blood network). This activation also decreases the levels of noradrenaline in the blood.
MAOB ADRA2A SLC18A2 SLC6A2 SLC18A2 SLC6A2 DDC DBH TH ALDH3A1 COMT Pargyline Norepinephrine Norepinephrine Norepinephrine Norepinephrine Pargyline Pargyline Pargyline L-Dopa Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water 3,4- Dihydroxymandelaldehyde NAD Water 3,4- Dihydroxymandelic acid NADH Hydrogen Ion S- Adenosylmethionine Vanillylmandelic acid S- Adenosylhomocysteine Water Oxygen Ammonia Hydrogen peroxide Gi/o signaling cascade