Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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5- hydroxytryptamine receptor 2C Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Agomelatine Ca+ Serotonin Agomelatine Agomelatine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Increase in dopamine and norepinephrine release Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ depressive symptoms Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Agomelatine binds to 5HT2C receptors and increases availability of dopamine and norepinephrine ↑Cognitive Improvement Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Agomelatine also acts a Melatonin MTI and MT2 receptor agonist Agomelatine is taken orally and absorbed from the gastrointestinal tract. Limbic system
HTR2C CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Agomelatine Calcium Serotonin Agomelatine Agomelatine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Increase in dopamine and norepinephrine release
HTR2C CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca2+ 5-HT 5-HT S20098 Ca2+ 5-HT S20098 S20098 Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ I i d a