Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 2C
Amine oxidase
[flavin-
containing] A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Phenelzine
Ca
+
Serotonin
Phenelzine
Phenelzine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
H
2
O
O
2
5-Hydroxyindoleacetic acid
H
2
O
2
NH
3
FAD
Fe2+
Pyridoxal
5'-phosphate
Gq signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
Mood Improvements
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal.
Serotonin activates 5HT2A
and 5HT2C receptors, which
are responsible for mood
improvements.
Blood-Brain Barrier
Diffusion
Hypothalamus
Phenelzine inhibits the
amine oxidase A and B. This
results in the decrease of
the metabolism of serotonin.
This inhibition results in
increased levels of
serotonin in the cytosol of
the neurons.
HTR2A
HTR2C
MAOA
CACNA1A
CACNB1
CACNA2D2
SLC18A2
TPH1
DDC
Calcium
Serotonin
Serotonin
Phenelzine
Calcium
Serotonin
Phenelzine
Phenelzine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Water
Oxygen
5-
Hydroxyindoleacetic
acid
Hydrogen
peroxide
Ammonia
Gq signaling
cascade