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5-
hydroxytryptamine
receptor 2A
5-
hydroxytryptamine
receptor 2C
5-
hydroxytryptamine
receptor 2B
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Amine oxidase
[flavin-
containing] A
Ca
+
Serotonin
Serotonin
Minaprine
Ca
+
Serotonin
Minaprine
Minaprine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
H
2
O
O
2
5-Hydroxyindoleacetic acid
H
2
O
2
NH
3
Fe2+
Pyridoxal
5'-phosphate
FAD
Gq signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
Mood Improvements
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal.
Minaprine activates 5HT2A,
5HT2B, and 5HT2C receptors,
which are responsible for
mood improvements through
the Gq signaling cascade.
Blood-Brain Barrier
Diffusion
HTR2A
HTR2C
HTR2B
CACNA1A
CACNB1
CACNA2D2
SLC18A2
TPH1
DDC
MAOA
Calcium
Serotonin
Serotonin
Minaprine
Calcium
Serotonin
Minaprine
Minaprine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Water
Oxygen
5-
Hydroxyindoleacetic
acid
Hydrogen
peroxide
Ammonia
Gq signaling
cascade
HTR2A