Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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5- hydroxytryptamine receptor 2A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Dosulepin Ca+ Serotonin Dosulepin Dosulepin L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Gq signaling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ depressive and anxiolytic symptoms Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Dosulepin binds to 5HT1A and 5HT2A where it exhibits antidepressive and anxiolytic properties Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier passive diffusion Dosulepin is administered orally Dosulepin also acts as an antagonist to D2, M1 and H1 receptors.
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Dosulepin Calcium Serotonin Dosulepin Dosulepin L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Dosul Ca+ 5-HT Dosul Dosul Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ depressive and anxiolytic symptoms Serotonin is synthesized at the raphei nuclei and stored in synaptic vesicles at the nerve terminal Dosulepin binds to 5HT1A and 5HT2A where it exhibits antidepressive and anxiolytic properties Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier passive diffusion Dosulepin is administered orally Dosulepin also acts as an antagonist to D2, M1 and H1 receptors.