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HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Quetiapine Calcium Serotonin Quetiapine Quetiapine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium Gq signaling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Quet Ca+ 5-HT Quet Quet Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P Gq si c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Negative symptoms of schizophrenia Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Quetiapine binds to 5HT2A where it acts as a functional antagonist to reduce negative symptoms of schizophrenia Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Quetiapine is taken orally is absorbed from the gastrointestinal tract
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca2+ 5-HT 5-HT Quet Ca2+ 5-HT Quet Quet Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Gq si c