Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
5-
hydroxytryptamine
receptor 2A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Pipotiazine
Ca
+
Serotonin
Pipotiazine
Pipotiazine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
Gq signaling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ schizophrenic, manic
bipolar and depressive
symptoms
Serotonin is synthesized at
the raphei nuclei and stored
in synaptic vesicles at the
nerve terminal
Pipotiazine binds to 5HT1A
and 5HT2A as an antagonist
where it exhibits
antidepressive and
antiaggressive properties.
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
passive diffusion
Pipotiazine is administered
orally
Pipotiazine also acts as an
antagonist to D1 and D2
receptors.
HTR2A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Calcium
Serotonin
Serotonin
Pipotiazine
Calcium
Serotonin
Pipotiazine
Pipotiazine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
Gq signaling
cascade
HTR2A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Ca
+
5-HT
5-HT
Piporti
Ca
+
5-HT
Piporti
Piporti
Trp
BH4
O
2
5-HTP
4aHtHbp
CO
2
Na
+
Na
+
Fe2+
Pyr-5'P
Gq si c
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ schizophrenic, manic
bipolar and depressive
symptoms
Serotonin is synthesized at
the raphei nuclei and stored
in synaptic vesicles at the
nerve terminal
Pipotiazine binds to 5HT1A
and 5HT2A as an antagonist
where it exhibits
antidepressive and
antiaggressive properties.
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
passive diffusion
Pipotiazine is administered
orally
Pipotiazine also acts as an
antagonist to D1 and D2
receptors.