Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
D(2) dopamine
receptor
D(1A) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Pipotiazine
Pipotiazine
Ca
+
Dopamine
Dopamine
Pipotiazine
Pipotiazine
Pipotiazine
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi signaling
cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Pipotiazine is a D1 - D4
receptor antagonist.
Dopamine receptors in the
mesolimbic pathway are
responsible for producing
the positive symptoms in
schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia and psychosis
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Passive Diffusion
Passive Diffusion
Pipotiazine is taken orally
DRD2
DRD1
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
Dopamine
Calcium
Pipotiazine
Pipotiazine
Calcium
Dopamine
Dopamine
Pipotiazine
Pipotiazine
Pipotiazine
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi signaling
cascade
DRD2
DRD1
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
LDP
Ca
+
Piporti
Piporti
Ca
+
LDP
LDP
Piporti
Piporti
Piporti
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi si c
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Pipotiazine is a D1 - D4
receptor antagonist.
Dopamine receptors in the
mesolimbic pathway are
responsible for producing
the positive symptoms in
schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia and psychosis
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
Brain
Mesolimbic pathway
Blood vessel - blood brain
barrier
Passive Diffusion
Passive Diffusion
Pipotiazine is taken orally