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Unknown
Unknown
Phenylalanine-
4-hydroxylase
Protein-
tyrosine
sulfotransferase
1
O-Sulfotyrosine
L-Phenylalanine
L-Phenylalanine
L-Phenylalanine
L-Phenylalanine
O-Sulfotyrosine
O
2
Tetrahydrobiopterin
L-Tyrosine
H
2
O
Dihydrobiopterin
3'-Phosphoadenylyl sulfate
Adenosine 3',5'-diphosphate
H
+
Fe2+
Chronic Kidney
Disease
End Stage Renal
Disease
Phenylalanine is obtained
from foods such as meat,
seafood, eggs, dairy, and
nuts
Intestinal Lumen
Intestinal Epithelial Cells
Intestinal Epithelial Cells
Golgi Apparatus
Hepatocyte
Tyrosine residues are
converted to sulfotyrosine
Golgi Apparatus
Unknown
Unknown
PAH
TPST1
O-Sulfotyrosine
L-Phenylalanine
L-Phenylalanine
L-Phenylalanine
L-Phenylalanine
O-Sulfotyrosine
Oxygen
Tetrahydrobiopterin
L-Tyrosine
Water
Dihydrobiopterin
3'-
Phosphoadenylyl
sulfate
Adenosine
3',5'-
diphosphate
Hydrogen
Chronic Kidney
Disease
End Stage Renal
Disease