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5- hydroxytryptamine receptor 2A Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Synaptic vesicular amine transporter Sodium- dependent serotonin transporter Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Ca+ Serotonin Serotonin Cyproheptadine Ca+ Serotonin Cyproheptadine Cyproheptadine L-Tryptophan Tetrahydrobiopterin O2 5-Hydroxy-L-tryptophan 4a-Hydroxytetrahydrobiopterin CO2 Na+ Na+ Fe2+ Pyridoxal 5'-phosphate GCPR signalling cascade Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Allergic responses Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Cyproheptadine binds to 5HT2A and 5HT2C Appetite stimulation Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Cyproheptadine is taken orally and absorbed from the gastrointestinal tract.
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Calcium Serotonin Serotonin Cyproheptadine Calcium Serotonin Cyproheptadine Cyproheptadine L-Tryptophan Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Carbon dioxide Sodium Sodium GCPR signalling cascade
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca+ 5-HT 5-HT Cyprohe Ca+ 5-HT Cyprohe Cyprohe Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ Fe2+ Pyr-5'P G s c Synaptic Vesicle Cytosol Cytosol Presynaptic Neuron Postsynaptic Neuron Synapse ↓ Allergic responses Serotonin is synthesized and stored in synaptic vesicles at the nerve terminal Cyproheptadine binds to 5HT2A and 5HT2C Appetite stimulation Brain Raphei nuclei producing serotonergic neurons Blood vessel -blood brain barrier Passive Diffusion Cyproheptadine is taken orally and absorbed from the gastrointestinal tract.
HTR2A CACNA1A CACNB1 CACNA2D2 SLC18A2 SLC6A4 TPH1 DDC Ca2+ 5-HT 5-HT Cyprohe Ca2+ 5-HT Cyprohe Cyprohe Trp BH4 O2 5-HTP 4aHtHbp CO2 Na+ Na+ G s c