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5-
hydroxytryptamine
receptor 2A
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Synaptic
vesicular amine
transporter
Sodium-
dependent
serotonin
transporter
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Ca
+
Serotonin
Serotonin
Cyproheptadine
Ca
+
Serotonin
Cyproheptadine
Cyproheptadine
L-Tryptophan
Tetrahydrobiopterin
O
2
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
CO
2
Na
+
Na
+
Fe2+
Pyridoxal
5'-phosphate
GCPR signalling
cascade
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Allergic responses
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Cyproheptadine binds to
5HT2A and 5HT2C
Appetite stimulation
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Passive Diffusion
Cyproheptadine is taken
orally and absorbed from the
gastrointestinal tract.
HTR2A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Calcium
Serotonin
Serotonin
Cyproheptadine
Calcium
Serotonin
Cyproheptadine
Cyproheptadine
L-Tryptophan
Tetrahydrobiopterin
Oxygen
5-Hydroxy-L-
tryptophan
4a-
Hydroxytetrahydrobiopterin
Carbon dioxide
Sodium
Sodium
GCPR signalling
cascade
HTR2A
CACNA1A
CACNB1
CACNA2D2
SLC18A2
SLC6A4
TPH1
DDC
Ca
+
5-HT
5-HT
Cyprohe
Ca
+
5-HT
Cyprohe
Cyprohe
Trp
BH4
O
2
5-HTP
4aHtHbp
CO
2
Na
+
Na
+
Fe2+
Pyr-5'P
G s c
Synaptic Vesicle
Cytosol
Cytosol
Presynaptic Neuron
Postsynaptic Neuron
Synapse
↓ Allergic responses
Serotonin is synthesized and
stored in synaptic vesicles
at the nerve terminal
Cyproheptadine binds to
5HT2A and 5HT2C
Appetite stimulation
Brain
Raphei nuclei producing
serotonergic neurons
Blood vessel -blood brain
barrier
Passive Diffusion
Cyproheptadine is taken
orally and absorbed from the
gastrointestinal tract.