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Pathway Description
Methysergide Mechanism of Action Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-08-29
Last Updated: 2023-11-27
Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle. Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, introduced in pharmacotherapy for migraine prophylaxis as a specific serotonin (5HT) receptor antagonist. Methysergide is not just a 5HT2 antagonist, it is also a 5HT1 agonist.
References
Methysergide Mechanism of Action Pathway References
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