Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
D(2) dopamine
receptor
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Aromatic-L-
amino-acid
decarboxylase
Tyrosine
3-monooxygenase
Dopamine
Ca
+
Clozapine
Ca
+
Dopamine
Dopamine
Clozapine
L-Dopa
CO
2
L-Tyrosine
Tetrahydrobiopterin
O
2
Dihydrobiopterin
H
2
O
Na
+
Na
+
Pyridoxal
5'-phosphate
Gi signaling
cascade
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Clozapine is a D2 receptor
antagonist. Dopamine
receptors in the mesolimbic
pathway are responsible for
producing the positive
symptoms in schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Brain
Mesolimbic pathway
Blood-Brain Barrier
Diffusion
Clozapine is taken orally
and absorbed from the
gastrointestinal tract
When action potential
arrives to the nerve
terminal, calcium channels
open causing influx of
calcium ions which trigger
the release of dopamine via
exocytosis.
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
Dopamine
Calcium
Clozapine
Calcium
Dopamine
Dopamine
Clozapine
L-Dopa
Carbon dioxide
L-Tyrosine
Tetrahydrobiopterin
Oxygen
Dihydrobiopterin
Water
Sodium
Sodium
Gi signaling
cascade
DRD2
CACNA1A
CACNB1
CACNA2D2
SLC6A3
SLC18A2
DDC
TH
LDP
Ca
+
Clozapi
Ca
+
LDP
LDP
Clozapi
L-Dopa
CO
2
Tyr
BH4
O
2
BH3
H
2
O
Na
+
Na
+
Pyr-5'P
Gi si c
Fe2+
Cytosol
Postsynaptic Neuron
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Synapse
Clozapine is a D2 receptor
antagonist. Dopamine
receptors in the mesolimbic
pathway are responsible for
producing the positive
symptoms in schizophrenia
↓ Positive, negative and
cognitive symptoms of
schizophrenia
Brain
Mesolimbic pathway
Blood-Brain Barrier
Diffusion
Clozapine is taken orally
and absorbed from the
gastrointestinal tract
When action potential
arrives to the nerve
terminal, calcium channels
open causing influx of
calcium ions which trigger
the release of dopamine via
exocytosis.
Excess dopamine in the brain
triggers positive symptoms
of schizophrenia