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Pathway Description
Clozapine Dopamine Antagonist Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-09-05
Last Updated: 2023-11-27
Clozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation antipsychotics or atypical antipsychotics. Antipsychotic drugs are vital in treating the core symptoms of schizophrenia: hallucinations and delusions As an atypical antipsychotic, clozapine acts an antagonist to both dopamine and serotonin receptors. Clozapine's antipsychotic action is likely mediated through a combination of antagonistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms. Side effects of clozapine include agranulocytosis, myocarditis, orthostatic hypotension, sedation, tachycardia, sexual dysfunction, urinary retention, constipation.
References
Clozapine Dopamine Antagonist Pathway References
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Pubmed: 7905859
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