Toggle navigation
SMPDB
Browse SMPDB
Pathways
Table of Primary Pathways
Compounds
Proteins
Search
TextQuery Search Instructions
SMP-MAP Advanced Search
ChemQuery Structure Search
Molecular Weight Search
Sequence Search
About
About SMPDB
Release Notes
Citing SMPDB
Statistics
Other Databases
Pathway Legend
Pathway Category Definitions
PathWhiz
Downloads
Contact Us
Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loading Pathway...
Error: Pathway image not found.
Myosin light
chain kinase,
smooth muscle
Adenylate
cyclase type 9
PKA complex
PKA complex
Protein kinase
C
G protein
complex
Myosin LC-P
Myosin light
chain 3
Inositol 1,4,5-
trisphosphate
receptor type 1
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
L-type calcium
channel subunit
alpha-1C
Myosin light
chain
phosphatase
Calmodulin
Intermediate
conductance
calcium-
activated
potassium
channel protein
4
Phospholipase C
Guanine
nucleotide-
binding protein
alpha
Guanine
nucleotide-
binding protein
gamma-beta
Calmodulin
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-1
Ca
+
Ca
+
Ca
+
K
+
K
+
GDP
GTP
ATP
cAMP
Inositol 1,4,5-trisphosphate
Phosphatidylinositol
4,5-bisphosphate
Diacylglycerol
GTP
P
i
P
i
P
i
Calcium
Ca
+
Histaminic
Receptor
Muscle
Contraction
Muscle
Relaxation
Magnesium
Calcium
Manganese
Sarcoplasmic Reticulum
Cytosol
Smooth Muscle Myocyte
The G protein complex
separates into alpha and
beta/gamma subunits.
GDP is replaced with GTP on
the alpha subunit.
Activated PKA can
phosphorylate calcium
activated potassium channels
causing potassium efflux and
promoting hyperpolarization.
Activated PKA phosphorylates
the IP3 receptor to reduce
its affinity for IP3.
Activated PKA phosphorylates
phospholipase C.
There is an overall decrease
in calcium levels in the
cytosol.
Decreased calcium is unable
to bind readily to
calmodulin.
The inhibition of myosin
light chain kinase prevents
the synthesis of Myosin LC-P
which leads to a high
concentration of myosin
light chain and muscle
relaxation.
Myosin unbinds from actin
causing sarcomere filaments
to slide resulting in muscle
relaxation.
Actin
Myosin
The histaminic receptor that
activate Gs signalling to
cause smooth muscle
relaxation is the H2
receptor
Histamine is a common
agonist of the H2 histaminic
receptor
MYLK
ADCY9
PRKAR1A
PRKAR2A
PRKCA
GNB1
MYL3
MYL3
ITPR1
CACNB1
CACNA1C
PPP1CB
CALM1
KCNN4
PLCB1
GNAS
GNGT1
CALM1
CACNA2D1
Calcium
Calcium
Calcium
Potassium
Potassium
Guanosine
diphosphate
Guanosine
triphosphate
Adenosine
triphosphate
cAMP
Inositol 1,4,5-
trisphosphate
Phosphatidylinositol
4,5-
bisphosphate
Diacylglycerol
Guanosine
triphosphate
Phosphate
Phosphate
Phosphate
Calcium
Histaminic
Receptor
Muscle
Contraction
Muscle
Relaxation
MYLK
ADCY9
PRKAR1A
PRKAR2A
PRKCA
GNB1
MYL3
MYL3
ITPR1
CACNB1
CACNA1C
PPP1CB
CALM1
KCNN4
PLCB1
GNAS
GNGT1
CALM1
CACNA2D1
Ca
+
Ca
+
Ca
+
K
+
K
+
GDP
GTP
ATP
cAMP
Inotp
P45P
Diacylg
GTP
P
i
P
i
P
i
Ca2+
Ca
+
His Rec
Mus Con
Mus Rel
Mg2+
Ca2+
Mn2+
Sarcoplasmic Reticulum
Cytosol
Smooth Muscle Myocyte
The G protein complex
separates into alpha and
beta/gamma subunits.
GDP is replaced with GTP on
the alpha subunit.
Activated PKA can
phosphorylate calcium
activated potassium channels
causing potassium efflux and
promoting hyperpolarization.
Activated PKA phosphorylates
the IP3 receptor to reduce
its affinity for IP3.
Activated PKA phosphorylates
phospholipase C.
There is an overall decrease
in calcium levels in the
cytosol.
Decreased calcium is unable
to bind readily to
calmodulin.
The inhibition of myosin
light chain kinase prevents
the synthesis of Myosin LC-P
which leads to a high
concentration of myosin
light chain and muscle
relaxation.
Myosin unbinds from actin
causing sarcomere filaments
to slide resulting in muscle
relaxation.
Actin
Myosin
The histaminic receptor that
activate Gs signalling to
cause smooth muscle
relaxation is the H2
receptor
Histamine is a common
agonist of the H2 histaminic
receptor