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D(2) dopamine receptor Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium- dependent dopamine transporter Synaptic vesicular amine transporter Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Dopamine Ca+ Metoclopramide Ca+ Dopamine Dopamine Metoclopramide L-Dopa CO2 L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Na+ Na+ Pyridoxal 5'-phosphate Gi signaling cascade Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Metoclopramide is a D2 receptor antagonist. Dopamine receptors in the area postrema or the vomiting centre of the brain, preventing vomit. Prevention of nausea and vomiting and stimulates gastric emptying. Brain Mesolimbic pathway Blood-Brain Barrier Diffusion Metoclopramide is taken orally or intravenously When action potential arrives to the nerve terminal, calcium channels open causing influx of calcium ions which trigger the release of dopamine via exocytosis. Excess dopamine in the brain triggers positive symptoms of schizophrenia
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH Dopamine Calcium Metoclopramide Calcium Dopamine Dopamine Metoclopramide L-Dopa Carbon dioxide L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Sodium Sodium Gi signaling cascade
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca+ Elieten Ca+ LDP LDP Elieten L-Dopa CO2 Tyr BH4 O2 BH3 H2O Na+ Na+ Pyr-5'P Gi si c Fe2+ Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Metoclopramide is a D2 receptor antagonist. Dopamine receptors in the area postrema or the vomiting centre of the brain, preventing vomit. Prevention of nausea and vomiting and stimulates gastric emptying. Brain Mesolimbic pathway Blood-Brain Barrier Diffusion Metoclopramide is taken orally or intravenously When action potential arrives to the nerve terminal, calcium channels open causing influx of calcium ions which trigger the release of dopamine via exocytosis. Excess dopamine in the brain triggers positive symptoms of schizophrenia
DRD2 CACNA1A CACNB1 CACNA2D2 SLC6A3 SLC18A2 DDC TH LDP Ca2+ Elieten Ca2+ LDP LDP Elieten L-Dopa CO2 Tyr BH4 O2 BH3