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cAMP-dependent
protein kinase
type II-beta
regulatory
subunit
D(4) dopamine
receptor
cAMP-dependent
protein kinase
catalytic
subunit alpha
cAMP-dependent
protein kinase
catalytic
subunit beta
cAMP-dependent
protein kinase
type I-alpha
regulatory
subunit
cAMP-dependent
protein kinase
catalytic
subunit gamma
cAMP-dependent
protein kinase
type I-beta
regulatory
subunit
cAMP-dependent
protein kinase
type II-alpha
regulatory
subunit
Guanine
nucleotide-
binding protein
G(I)/G(S)/G(T)
subunit beta-1
Gγ
Adenylate
cyclase type 10
Sodium-
dependent
dopamine
transporter
Synaptic
vesicular amine
transporter
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Voltage-
dependent
N-type calcium
channel subunit
alpha-1B
Tyrosine
3-monooxygenase
Aromatic-L-
amino-acid
decarboxylase
Dopamine
Ca
+
Dopamine
cAMP
Sibutramine
Dopamine
Ca
+
Sibutramine
Sibutramine
L-Tyrosine
L-Dopa
CO
2
ATP
Magnesium
Fe2+
Pyridoxal
5'-phosphate
Guanine
nucleotide-
binding protein
G(i) subunit
alpha-1
Neuronal
Excitability
The inhibition of dopamine
reuptake receptors by
Sibutramine causes more
dopamine to accumulate in
the synapse, causing the
continual activation of the
D4 Dopamine receptor
Activation of D4 dopamine
receptors activates the Gi
signalling cascade which
leads to reduced cAMP.
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Dopamine is produced in the
Ventral Tegmental Area of
the brain
Prefrontal Cortex
Reduced cAMP results in
decreased neural
excitability. This results
in reduced movement and
impulsivity. Although the
exact mechanisms are
unknown.
Synapse
Prefrontal Cortex
Increased dopamine activates
D4 dopamine receptors in the
prefrontal cortex
In low doses, Sibutramine
selectively activates
dopamine neurotransmission,
Blood-Brain Barrier
Diffusion
PRKAR2B
DRD4
PRKACA
PRKACB
PRKAR1A
PRKACG
PRKAR1B
PRKAR2A
GNB1
GNG2
ADCY10
SLC6A3
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
TH
DDC
Dopamine
Calcium
Dopamine
cAMP
Sibutramine
Dopamine
Calcium
Sibutramine
Sibutramine
L-Tyrosine
L-Dopa
Carbon dioxide
Adenosine
triphosphate
GNAI1
Neuronal
Excitability
PRKAR2B
DRD4
PRKACA
PRKACB
PRKAR1A
PRKACG
PRKAR1B
PRKAR2A
GNB1
GNG2
ADCY10
SLC6A3
SLC18A2
CACNA2D1
CACNA2D2
CACNA1B
TH
DDC
LDP
Ca
+
LDP
cAMP
Butrami
LDP
Ca
+
Butrami
Butrami
Tyr
L-Dopa
CO
2
ATP
Mg2+
Fe2+
Pyr-5'P
GNAI1
Neu Exc
The inhibition of dopamine
reuptake receptors by
Sibutramine causes more
dopamine to accumulate in
the synapse, causing the
continual activation of the
D4 Dopamine receptor
Activation of D4 dopamine
receptors activates the Gi
signalling cascade which
leads to reduced cAMP.
Presynaptic Neuron
Cytosol
Synaptic Vesicle
Postsynaptic Neuron
Cytosol
Dopamine is produced in the
Ventral Tegmental Area of
the brain
Prefrontal Cortex
Reduced cAMP results in
decreased neural
excitability. This results
in reduced movement and
impulsivity. Although the
exact mechanisms are
unknown.
Synapse
Prefrontal Cortex
Increased dopamine activates
D4 dopamine receptors in the
prefrontal cortex
In low doses, Sibutramine
selectively activates
dopamine neurotransmission,
Blood-Brain Barrier
Diffusion