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Histamine H1 receptor Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Histidine decarboxylase Histamine Bromodiphenhydramine Ca+ Histamine Histamine Ca+ Bromodiphenhydramine Bromodiphenhydramine L-Histidine CO2 Pyridoxal 5'-phosphate Depolarization Postsynaptic Neuron Cytosol Presynaptic Neuron Synaptic Vesicle Cytosol Tuberomammillary nucleus The depolarization of the tuberomammillary nucleus sends signals to all major areas of the brain and causes wakefulness. Therefore, the inhibition of histamine receptors causes sleepiness Diffusion
HRH1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B HDC Histamine Bromodiphenhydramine Calcium Histamine Histamine Calcium Bromodiphenhydramine Bromodiphenhydramine L-Histidine Carbon dioxide Depolarization
HRH1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B HDC Hsm Bromdip Ca+ Hsm Hsm Ca+ Bromdip Bromdip His CO2 Pyr-5'P Depol Postsynaptic Neuron Cytosol Presynaptic Neuron Synaptic Vesicle Cytosol Tuberomammillary nucleus The depolarization of the tuberomammillary nucleus sends signals to all major areas of the brain and causes wakefulness. Therefore, the inhibition of histamine receptors causes sleepiness Diffusion
HRH1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B HDC Hsm Bromdip Ca2+ Hsm Hsm Ca2+ Bromdip Bromdip His CO2 Depol