SMPDB

Pathway Description

Vardenafil Predicted Metabolism Pathway

Homo sapiens

Metabolic Pathway

Created: 2023-12-07

Last Updated: 2024-02-03

Metabolites of Vardenafil are predicted with biotransformer.

References

Vardenafil Predicted Metabolism Pathway References

Wishart DS, Tian S, Allen D, Oler E, Peters H, Lui VW, Gautam V, Djoumbou-Feunang Y, Greiner R, Metz TO: BioTransformer 3.0-a web server for accurately predicting metabolic transformation products. Nucleic Acids Res. 2022 Jul 5;50(W1):W115-W123. doi: 10.1093/nar/gkac313.

Pubmed: 35536252

Hsieh KP, Lin YY, Cheng CL, Lai ML, Lin MS, Siest JP, Huang JD: Novel mutations of CYP3A4 in Chinese. Drug Metab Dispos. 2001 Mar;29(3):268-73.

Pubmed: 11181494

Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5311-5. doi: 10.1073/pnas.83.14.5311.

Pubmed: 3460094

Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA. 1988 Mar;7(2):79-86. doi: 10.1089/dna.1988.7.79.

Pubmed: 3267210

Highlighted elements will appear in red.

Highlight Compounds

	Heme
	Vardenafil
	Vardenafil PIS1M1
	Vardenafil PIS1M2
	Vardenafil PIS2M1

Highlight Proteins

	Cytochrome P450 3A4
	Unknown

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data