SMPDB

Pathway Description

Ambrisentan Predicted Metabolism Pathway

Homo sapiens

Metabolic Pathway

Created: 2023-12-13

Last Updated: 2024-02-03

Metabolites of Ambrisentan are predicted with biotransformer.

References

Ambrisentan Predicted Metabolism Pathway References

Wishart DS, Tian S, Allen D, Oler E, Peters H, Lui VW, Gautam V, Djoumbou-Feunang Y, Greiner R, Metz TO: BioTransformer 3.0-a web server for accurately predicting metabolic transformation products. Nucleic Acids Res. 2022 Jul 5;50(W1):W115-W123. doi: 10.1093/nar/gkac313.

Pubmed: 35536252

Hsieh KP, Lin YY, Cheng CL, Lai ML, Lin MS, Siest JP, Huang JD: Novel mutations of CYP3A4 in Chinese. Drug Metab Dispos. 2001 Mar;29(3):268-73.

Pubmed: 11181494

Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5311-5. doi: 10.1073/pnas.83.14.5311.

Pubmed: 3460094

Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA. 1988 Mar;7(2):79-86. doi: 10.1089/dna.1988.7.79.

Pubmed: 3267210

Highlighted elements will appear in red.

Highlight Compounds

	Ambrisentan
	Ambrisentan PIS1M1
	Ambrisentan PIS1M2
	Ambrisentan PIS2M1
	Ambrisentan PIS2M2
	Ambrisentan PIS4M1
	Heme

Highlight Proteins

	Cytochrome P450 3A4
	Unknown

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