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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Tetradecyl hydrogen sulfate (ester) Tetradecyl hydrogen sulfate (ester) Tetradecyl hydrogen sulfate (ester) PIS1M1 Tetradecyl hydrogen sulfate (ester) PIS1M2 Tetradecyl hydrogen sulfate (ester) PIS1M2 Tetradecyl hydrogen sulfate (ester) PIS1M3 Tetradecyl hydrogen sulfate (ester) PIS1M3 Tetradecyl hydrogen sulfate (ester) PIS2M1 Tetradecyl hydrogen sulfate (ester) PIS2M1 Tetradecyl hydrogen sulfate (ester) PIS1M4 Tetradecyl hydrogen sulfate (ester) PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tetradecyl hydrogen sulfate (ester) undergoes metabolism to give Tetradecyl hydrogen sulfate (ester) PIS1M1, Tetradecyl hydrogen sulfate (ester) PIS1M2, Tetradecyl hydrogen sulfate (ester) PIS1M3, Tetradecyl hydrogen sulfate (ester) PIS1M4 and Tetradecyl hydrogen sulfate (ester) PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Tetradecyl hydrogen sulfate (ester) Tetradecyl hydrogen sulfate (ester) Tetradecyl hydrogen sulfate (ester) PIS1M1 Tetradecyl hydrogen sulfate (ester) PIS1M2 Tetradecyl hydrogen sulfate (ester) PIS1M2 Tetradecyl hydrogen sulfate (ester) PIS1M3 Tetradecyl hydrogen sulfate (ester) PIS1M3 Tetradecyl hydrogen sulfate (ester) PIS2M1 Tetradecyl hydrogen sulfate (ester) PIS2M1 Tetradecyl hydrogen sulfate (ester) PIS1M4 Tetradecyl hydrogen sulfate (ester) PIS1M1 Urinary Excretion and/or Bile duct Excretion