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Gq protein
signaling cascade
Phospholipase C
Protein kinase C
alpha type
Histamine H1
receptor
Nitric oxide
synthase,
endothelial
Myosin light
chain phosphatase
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Inositol 1,4,5-
trisphosphate
receptor type 1
Myosin LC-P
Myosin light
chain 3
Calmodulin-1
Myosin light
chain kinase,
smooth muscle
Calmodulin-1
Histamine
NO
Inositol 1,4,5-
trisphosphate
Azelastine
NO
Ca
+
Ca
+
Ca
+
Azelastine
Phosphatidylinositol
4,5-bisphosphate
L-Arginine
H
+
NADPH
O
2
H
2
O
Citrulline
NADP
Calcium
Heme
FAD
Flavin
Mononucleotide
Tetrahydrobiopterin
Ca
+
Diacylglycerol
Muscle
Contraction
Muscle
relaxation
Mast Cells
Release Histamine