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Melanosome Endoplasmic Reticulum Nucleus PRKCB NFKB1 GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 HRH1 Inositol 1,4,5- trisphosphate Histamine Promethazine Calcium Calcium Promethazine Phosphatidylinositol 4,5-bisphosphate Diacylglycerol Mast Cells Release Histamine Calcium
PRKCB NFKB1 GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 HRH1 Inotp Hsm Prometh Ca+ Ca+ Prometh P45P Ca2+ ↑ Mediator Release Diacylg ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors M C R H Ca+ Ca2+ Nucleus ↑ Antigen Presentation ↓ Mast Cell Stabilization Endoplamic Reticulum There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol T Cell Promethazine antagonizes Histamine H1 receptors in endothelial cells, preventing histamine from activating the receptor T Cell
Melanosome Endoplasmic Reticulum Nucleus PRKCB NFKB1 GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 HRH1 Inotp Hsm Prometh Ca2+ Ca2+ Prometh P45P Diacylg M C R H Ca2+