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40S ribosomal protein S8 Eukaryotic translation initiation factor 1 Eukaryotic translation initiation factor 3 subunit A Eukaryotic translation initiation factor 5 40S ribosomal protein S2 60S acidic ribosomal protein P1 Small 40S Ribosomal Subunit 40S ribosomal protein S30 60S ribosomal protein L10 60S ribosomal protein L10a 60S ribosomal protein L11 60S ribosomal protein L12 60S ribosomal protein L13 60S ribosomal protein L13a 60S ribosomal protein L14 60S ribosomal protein L15 60S ribosomal protein L17 60S ribosomal protein L18 60S ribosomal protein L18a 60S ribosomal protein L19 60S ribosomal protein L21 60S ribosomal protein L22 60S ribosomal protein L23 60S ribosomal protein L23a 60S ribosomal protein L24 60S ribosomal protein L26 60S ribosomal protein L27 60S ribosomal protein L27a 60S ribosomal protein L28 60S ribosomal protein L29 60S ribosomal protein L3 60S ribosomal protein L30 60S ribosomal protein L31 60S ribosomal protein L32 60S ribosomal protein L34 60S ribosomal protein L35 60S ribosomal protein L35a 60S ribosomal protein L36 60S ribosomal protein L36a 60S ribosomal protein L37 60S ribosomal protein L37a 60S ribosomal protein L38 60S ribosomal protein L39 60S ribosomal protein L4 60S ribosomal protein L41 60S ribosomal protein L5 60S ribosomal protein L6 60S ribosomal protein L7 60S ribosomal protein L7a 60S ribosomal protein L8 60S ribosomal protein L9 60S acidic ribosomal protein P0 60S acidic ribosomal protein P1 60S acidic ribosomal protein P2 40S ribosomal protein S10 40S ribosomal protein S11 40S ribosomal protein S12 40S ribosomal protein S13 40S ribosomal protein S14 40S ribosomal protein S15 40S ribosomal protein S15a 40S ribosomal protein S16 40S ribosomal protein S17 40S ribosomal protein S18 40S ribosomal protein S19 40S ribosomal protein S2 40S ribosomal protein S20 40S ribosomal protein S21 40S ribosomal protein S23 40S ribosomal protein S24 40S ribosomal protein S25 40S ribosomal protein S26 40S ribosomal protein S27 Ubiquitin-40S ribosomal protein S27a 40S ribosomal protein S28 40S ribosomal protein S29 40S ribosomal protein S3 40S ribosomal protein S3a 40S ribosomal protein S4, X isoform 40S ribosomal protein S5 40S ribosomal protein S6 40S ribosomal protein S7 40S ribosomal protein S9 40S ribosomal protein SA Ubiquitin-60S ribosomal protein L40 EIF2S1 EIF2S2 EIF2S1 EIF2S2 Eukaryotic translation initiation factor 2 subunit 1 40S ribosomal protein S16 Eukaryotic initiation factor 4A-I Eukaryotic translation initiation factor 1 Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 3 subunit A Eukaryotic initiation factor 4A-I Eukaryotic translation initiation factor 5 40S ribosomal protein S2 Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic initiation factor 4A-I Eukaryotic translation initiation factor 1 Eukaryotic translation initiation factor 3 subunit A Eukaryotic translation initiation factor 5 GTP ATP ADP Pi GTP tRNA(Met) GTP tRNA(Met) GTP tRNA(Met) tRNA(Met) tRNA(Met) Translation Elongation: Alanine Ternary complex 43S complex 48S complex Extracellular Space Cytosol When the preinitiation complex finds the initiator codon, the pairing of the Met anticodon and AUG elicits the joining of the 60S ribosomal subunit to form the active ribosome. Recruitment of mRNA to the 43S complex is mediated by the eIF4 group of factors Active 80S ribosome, competent for elongation
RPS8 EIF1 EIF3A EIF5 RPS2 RPLP1 RPS2 FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS5 RPS6 RPS7 RPS9 RPSA UBA52 EIF2S1 EIF2S2 EIF2S1 EIF2S2 EIF2S1 RPS16 EIF4A1 EIF1 EIF2S1 EIF3A EIF4A1 EIF5 RPS2 EIF2S1 EIF2S2 EIF4A1 EIF1 EIF3A EIF5 Guanosine triphosphate Adenosine triphosphate Adenosine diphosphate Phosphate Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate tRNA(Met) tRNA(Met) Translation Elongation: Alanine
RPS8 EIF1 EIF3A EIF5 RPS2 RPLP1 RPS2 FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS5 RPS6 RPS7 RPS9 RPSA UBA52 EIF2S1 EIF2S2 EIF2S1 EIF2S2 EIF2S1 RPS16 EIF4A1 EIF1 EIF2S1 EIF3A EIF4A1 EIF5 RPS2 EIF2S1 EIF2S2 EIF4A1 EIF1 EIF3A EIF5 GTP ATP ADP Pi GTP tRNA( GTP tRNA( GTP tRNA( TRNAMET TRNAMET PW696492 Ternary complex 43S complex 48S complex Extracellular Space Cytosol When the preinitiation complex finds the initiator codon, the pairing of the Met anticodon and AUG elicits the joining of the 60S ribosomal subunit to form the active ribosome. Recruitment of mRNA to the 43S complex is mediated by the eIF4 group of factors Active 80S ribosome, competent for elongation
RPS8 EIF1 EIF3A EIF5 RPS2 RPLP1 RPS2 FAU RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL4 RPL41 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS2 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS3 RPS3A RPS4X RPS5 RPS6 RPS7 RPS9 RPSA UBA52 EIF2S1 EIF2S2 EIF2S1 EIF2S2 EIF2S1 RPS16 EIF4A1 EIF1 EIF2S1 EIF3A EIF4A1 EIF5 RPS2 EIF2S1 EIF2S2 EIF4A1 EIF1 EIF3A EIF5 GTP ATP ADP Pi GTP GTP GTP TRNAMET TRNAMET PW696492