Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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Phosphate Prolactin Prolactin receptor Tyrosine-protein kinase JAK2 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 Signal transducer and activator of transcription 5A Suppressor of cytokine signaling 2 Insulin receptor substrate 1 SHC-transforming protein 1 Growth factor receptor-bound protein 2 Son of sevenless homolog 1 Prolactin Insulin receptor substrate 1 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit delta isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Signal transducer and activator of transcription 5A Suppressor of cytokine signaling 2 Prolactin Suppressor of cytokine signaling 3 Cytokine- inducible SH2-containing protein Interferon regulatory factor 1 Beta-casein Tyrosine-protein kinase JAK2 Dopamine Pi Pi Pi Pi MAPK/ERK mTOR Negative Feedback Prolactin from the pituitary binds and activates the PRLR dimer at the mammary epithelial cell surface Activated JAK2 phosphorylates the PRLR intracellular domain, creating docking sites for STAT5A. JAK2 phosphorylates STAT5A, enabling STAT5A dimer formation. SOCS proteins inhibit PRLR–JAK2 signaling; PIAS and phosphatases further restrain STAT5 activity. Milk protein gene transcriptionally activated by STAT5A Transcription factor activated by JAK2, forming dimers that regulate lactation and survival genes. STAT5A induces IRF1 expression, linking prolactin signaling to immune and apoptotic gene regulation ERK signaling to promote cell proliferation and differentiation, mTOR to support cell survival, metabolism, and protein synthesis Pituitary Gland Dopamine can negatively regulate the release of prolactin from the brain Mammary epithelial cell Extracellular Space Cytosol Nucleus
Nucleus PRL PRLR JAK2 AGAP2 STAT5A SOCS2 Unknown Unknown GRB2 SOS1 PRL Unknown PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 STAT5A SOCS2 PRL SOCS3 CISH IRF1 CSN2 JAK2 Dopamine Phosphate Phosphate Phosphate Phosphate MAPK/ERK mTOR