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Pathway Description
Glucagon signaling pathway
Homo sapiens
Signaling Pathway
Created: 2025-09-18
Last Updated: 2025-11-09
Glucagon is a peptide notable for its action in glucose homeostasis. It is secreted in response to a multitude of different signals, predominantly in low glucose concentration. It is also known to secrete in response to free fatty acids and stress. In hypoglycemic conditions, the secretion of glucagon increases to create increased hepatic glucose production. Glucagon binds the transmembrane receptor on the plasma membrane of the cell to generate the conformational change that initiates the Gas coupled proteins.
References
Glucagon signaling pathway References
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Pubmed: 3426618
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Pubmed: 15489334
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