AKT1 Serum response factor ROCK1 Inositol 1,4,5- trisphosphate receptor type 1 LPAR2 LPAR2 Inositol 1,4,5- trisphosphate Ca+ Ca+ ATP cAMP PPi H2O Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 1,2-diacyl- sn-glycerol PKC Lysophosphatidic acid phosphatidylinositol 4,5- bisphosphate Gαi/o Gα12/13 Gαq/11 Lysophosphatidic acid Magnesium Phospholipid Biosynthesis Magnesium Calcium GTP GTP GTP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors GDP Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane Created with Snap
Endoplasmic Reticulum GNG2 GNG2 AKT1 SRF ROCK1 ITPR1 GNB1 GNB1 LPAR2 LPAR2 Inositol 1,4,5- trisphosphate Calcium Calcium Adenosine triphosphate cAMP Pyrophosphate Water Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 1,2-diacyl- sn-glycerol PKC Lysophosphatidic acid phosphatidylinositol 4,5- bisphosphate Gαi/o Gα12/13 Gαq/11 Lysophosphatidic acid Phospholipid Biosynthesis Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate Guanosine diphosphate Created with Snap
GNG2 GNG2 AKT1 SRF ROCK1 ITPR1 GNB1 GNB1 LPAR2 LPAR2 Inotp Ca+ Ca+ ATP cAMP PPi H2O AC Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 12DSG PKC LA P45B Gαi/o Gα12/13 Gαq/11 LA Mg2+ PW000048 Mg2+ Ca2+ GTP GTP GTP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors GDP Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane Created with Snap
Endoplasmic Reticulum GNG2 GNG2 AKT1 SRF ROCK1 ITPR1 GNB1 GNB1 LPAR2 LPAR2 Inotp Ca2+ Ca2+ ATP cAMP Ppi H2O AC Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 12DSG PKC LA P45B Gαi/o Gα12/13 Gαq/11 LA PW000048 GTP GTP GTP GTP GDP Created with Snap