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Showing 127011 - 127020 of 605359 pathways
SMPDB ID Pathway Name and Description Pathway Class Chemical Compounds Proteins

SMP0142761

Pw144429 View Pathway

Flucloxacillin Drug Metabolism Action Pathway

Drug Action

SMP0142756

Pw144424 View Pathway

Ropivacaine Drug Metabolism Action Pathway

Drug Action

SMP0142768

Pw144436 View Pathway

Ibutilide Drug Metabolism Action Pathway

Drug Action

SMP0142749

Pw144417 View Pathway

Atomoxetine Drug Metabolism Action Pathway

Drug Action

SMP0142744

Pw144412 View Pathway

Acarbose Drug Metabolism Action Pathway

Drug Action

SMP0190623

Missing View Pathway

Cardiolipin Biosynthesis CL(12:0/16:0/16:0/17:0)

Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism (Wikipedia). Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum. This second route may supplement this pathway. All membrane-localized enzymes are coloured dark green in the image. First, dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). Third, the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (PA or 1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. PA is then transferred to the inner mitochondrial membrane to continue cardiolipin synthesis. Fourth, magnesium-dependent phosphatidate cytidylyltransferase catalyzes the conversion of PA into CDP-diacylglycerol. Fifth, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). Last, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor.
Metabolic

SMP0143261

Pw144929 View Pathway

Ethynodiol diacetate Drug Metabolism Action Pathway

Drug Action

SMP0143287

Pw144955 View Pathway

Perphenazine Drug Metabolism Action Pathway

Drug Action

SMP0143275

Pw144943 View Pathway

Clocortolone Drug Metabolism Action Pathway

Drug Action

SMP0143282

Pw144950 View Pathway

Clofazimine Drug Metabolism Action Pathway

Drug Action
Showing 127011 - 127020 of 140989 pathways