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Showing 126911 - 126920 of 605359 pathways
SMPDB ID Pathway Name and Description Pathway Class Chemical Compounds Proteins

SMP0143665

Pw145333 View Pathway

Isocarboxazid Drug Metabolism Action Pathway

Drug Action

SMP0143672

Pw145340 View Pathway

Lisdexamfetamine Drug Metabolism Action Pathway

Drug Action

SMP0143658

Pw145326 View Pathway

Epoprostenol Drug Metabolism Action Pathway

Drug Action
  • Epoprostenol

SMP0190774

Missing View Pathway

Cardiolipin Biosynthesis CL(12:0/16:0/a-21:0/a-25:0)

Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism (Wikipedia). Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum. This second route may supplement this pathway. All membrane-localized enzymes are coloured dark green in the image. First, dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). Third, the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (PA or 1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. PA is then transferred to the inner mitochondrial membrane to continue cardiolipin synthesis. Fourth, magnesium-dependent phosphatidate cytidylyltransferase catalyzes the conversion of PA into CDP-diacylglycerol. Fifth, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). Last, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor.
Metabolic

SMP0143841

Pw145509 View Pathway

Thymol Drug Metabolism Action Pathway

Drug Action

SMP0143848

Pw145516 View Pathway

Sucrose Drug Metabolism Action Pathway

Drug Action

SMP0143862

Pw145530 View Pathway

Flavin mononucleotide Drug Metabolism Action Pathway

Drug Action

SMP0143860

Pw145528 View Pathway

Stearic acid Drug Metabolism Action Pathway

Drug Action

SMP0143843

Pw145511 View Pathway

Vorinostat Drug Metabolism Action Pathway

Drug Action

SMP0143836

Pw145504 View Pathway

Cocarboxylase Drug Metabolism Action Pathway

Drug Action
  • Cocarboxylase
Showing 126911 - 126920 of 140988 pathways