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Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Solute carrier
family 22
member 6
Solute carrier
family 22
member 8
Cytochrome P450
3A4
Cytochrome P450
2C8
Cytochrome P450
2C19
Cytochrome P450
2C9
Cytochrome P450
2C9
Cytochrome P450
2C19
Cytochrome P450
2C8
UDP-
glucuronosyltransferase
2B7
UDP-
glucuronosyltransferase
2B4
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-3
UDP-
glucuronosyltransferase
1-9
UDP-
glucuronosyltransferase
1-10
Cytochrome P450
2C9
Ibuprofen
Ibuprofen
1-Hydroxyibuprofen
O
2
NADPH
H
+
2-Hydroxyibuprofen
H
2
O
NADP
O
2
NADPH
H
+
3-Hydroxyibuprofen
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
Ibuprofen glucuronide
Uridine
5'-diphosphate
H
2
O
O
2
Carboxy-ibuprofen
H
2
O
2
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Endoplasmic Reticulum
Membrane
Endoplasmic Reticulum
PTGS2
PTGS1
SLC22A6
SLC22A8
CYP3A4
CYP2C8
CYP2C19
CYP2C9
CYP2C9
CYP2C19
CYP2C8
UGT2B7
UGT2B4
UGT1A1
UGT1A3
UGT1A9
UGT1A10
CYP2C9
Ibuprofen
Ibuprofen
1-
Hydroxyibuprofen
Oxygen
NADPH
Hydrogen Ion
2-
Hydroxyibuprofen
Water
NADP
Oxygen
NADPH
Hydrogen Ion
3-
Hydroxyibuprofen
Water
NADP
Uridine
diphosphate
glucuronic acid
Ibuprofen
glucuronide
Uridine
5'-diphosphate
Water
Oxygen
Carboxy-
ibuprofen
Hydrogen
peroxide
PTGS2
PTGS1
SLC22A6
SLC22A8
CYP3A4
CYP2C8
CYP2C19
CYP2C9
CYP2C9
CYP2C19
CYP2C8
UGT2B7
UGT2B4
UGT1A1
UGT1A3
UGT1A9
UGT1A10
CYP2C9
Ibuprfn
Ibuprfn
1Hibupf
O
2
NADPH
H
+
IbuOH
H
2
O
NADP
O
2
NADPH
H
+
3-HIbup
H
2
O
NADP
UDPGlcA
Ibuprof
UDP
H
2
O
O
2
C-ibupf
H
2
O
2
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Endoplasmic Reticulum
Membrane