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Sodium-
dependent
noradrenaline
transporter
Sodium-
dependent
serotonin
transporter
Cytochrome P450
2D6
Cytochrome P450
2C19
Cytochrome P450
1A2
Cytochrome P450
3A4
Desipramine
Desipramine
2-hydroxyimipramine
2-Hydroxy-imipramine
glucuronide
Imipramine
O
2
NADPH
H
+
H
2
O
NADP
O
2
NADH
H
2
O
Formaldehyde
NAD
Heme
Heme
Heme
Heme
Desipramine
Pathway
Axon Terminal
SLC6A2
SLC6A4
CYP2D6
CYP2C19
CYP1A2
CYP3A4
Desipramine
Desipramine
2-
hydroxyimipramine
2-Hydroxy-
imipramine
glucuronide
Imipramine
Oxygen
NADPH
Hydrogen Ion
Water
NADP
Oxygen
NADH
Water
Formaldehyde
NAD
Desipramine
Pathway
SLC6A2
SLC6A4
CYP2D6
CYP2C19
CYP1A2
CYP3A4
Desipra
Desipra
2Hi
2hig
Impramn
O
2
NADPH
H
+
H
2
O
NADP
O
2
NADH
H
2
O
Formol
NAD
Heme
Heme
Heme
Heme
PW000425
Axon Terminal