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Nicotinamide phosphoribosyltransferase NAD-dependent protein deacetylase sirtuin-1 Atrial natriuretic peptide receptor 1 Circadian locomoter output cycles protein kaput NAD kinase NAD(P)H dehydrogenase [quinone] 1 Nicotinamide mononucleotide adenylyltransferase 1 Nicotinamide mononucleotide adenylyltransferase 2 Nicotinamide mononucleotide adenylyltransferase 3 Peroxisome proliferator- activated receptor gamma coactivator 1-alpha Nuclear receptor ROR-alpha Daporinad CHS-828 NAD Niacinamide Phosphoribosyl pyrophosphate Nicotinic acid mononucleotide Phosphate NADP NADPH ADP Ribose FAD Poly [ADP-ribose] polymerase Cytoplasm Levels of NAMPT decline during aging BMAL1/CLOCK complex controls Nampt gene encoding Aging is associated with an increase in chronic nuclear DNA damage, which leads to NAD+ depletion by PARP NAD+ is produced by NAMPT, and NAD+ will activate NAD-dependent protein sitruin-1, which will active NAMPT. When DNA damage activate PARP, it takes over the available NAD+; hence the NAMPT can't be activated. This causes aging Nucleus Mitochondria Golgi Apparatus
NAMPT SIRT1 NPR1 CLOCK NADK NQO1 NMNAT1 NMNAT2 NMNAT3 PPARGC1A RORA Daporinad CHS-828 NAD Niacinamide Phosphoribosyl pyrophosphate Nicotinic acid mononucleotide Phosphate NADP NADPH ADP Ribose Poly [ADP-ribose] polymerase
NAMPT SIRT1 NPR1 CLOCK NADK NQO1 NMNAT1 NMNAT2 NMNAT3 PPARGC1A RORA Daporin CHS829 NAD Nam PRPP Nicotam Phos NADP NADPH ADPrib FAD PARP Cytoplasm Levels of NAMPT decline during aging BMAL1/CLOCK complex controls Nampt gene encoding Aging is associated with an increase in chronic nuclear DNA damage, which leads to NAD+ depletion by PARP NAD+ is produced by NAMPT, and NAD+ will activate NAD-dependent protein sitruin-1, which will active NAMPT. When DNA damage activate PARP, it takes over the available NAD+; hence the NAMPT can't be activated. This causes aging Nucleus Mitochondria Golgi Apparatus
NAMPT SIRT1 NPR1 CLOCK NADK NQO1 NMNAT1 NMNAT2 NMNAT3 PPARGC1A RORA Daporin CHS829 NAD Nam PRPP Nicotam Phos NADP NADPH ADPrib PARP