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Matched Description: Aldosterone is a hormone produced in the zona glomerulosa of the adrenal cortex. It's function is … to act on the distal convoluted tubule and the collecting duct of the nephron to make them more … membrane, activating the G protein and triggering a signaling cascade. The end result is the activation of … mitochondria. From there, cholesterol undergoes a series of reactions in both the mitochondrion and the … smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone.

Matched Compounds: Aldosterone

Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone

Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … , heart, and kidney. Lung possesses the highest amount of ACE. Expression of ACE is affected by steroids … and thyroid hormone, but the details of the regulation are not clear. ACE is under promoter

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: the plasma forming a strong activator complex. This activator complex of VIIa and TF converts factor … Coagulation of the blood can be initiation from two different pathways that both result in … formation of thrombin which converts blood soluble fibrinogen into the insoluble fibrin clot at the site of … injury. The intrinsic pathway is activated by trauma inside vasculature and is activated by … platelets, exposed endothelium and collagen. In the liver the coagulation factors VII, IX, and X are

Matched Compound Synonyms: 11-deoxy-cortisol … 11-dioxy-cortisol … 11-deoxy-cortisol … 11-dioxy-cortisol

Matched Description: steroidogenesis, which is a process that ultimately leads to the synthesis of aldosterone from … cholesterol. Aldosterone then goes to act on the distal convoluted tubule and the collecting duct to make … Angiotensin is a peptide hormone that is part of the renin-angiotensin system responsible for … regulating fluid homeostasis and blood pressure. It is involved in various means to increase the body's … blood pressure, hence why it is a target for many pharmceutical drugs that treat hypertension and

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of … water and ions. It is composed of two important cell types: intercalated cells that are responsible

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: the release of aldosterone from the adrenal cortex and release of vasopressin from the posterior … The distal convoluted tubule of the nephron is the part of the kidney between the loop of henle and … , aldosterone is a major regulator of the reabsorption of these ions as well, as it changes the … , chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure. … the collecting duct. When renin is released from the kidneys, it causes the activation of

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: The proximal convoluted tubule is part of the nephron between the Bowman's capsule and the loop of … and apical membranes, respectively, to effectively regulate the pH of the filtrate. In addition … Henle. The proximal convoluted tubule functions to reabsorb sodium, water, and other ions. Sodium … and bicarbonate (hydrogen carbonate) are transported by a co-transporter that is responsible for the … majority of sodium reabsorption. The bicarbonate, along with hydrogen, are exchanged across the basal

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Description: The loop of Henle of the nephron can be separated into an ascending limb and the descending limb … water reabsorption into the adjacent capillary network and a high concentration of sodium in the … being actively transported out of the ascending limb, the solutes cause in increase in osmotic … pressure. This, combined with the ability for water to move freely out of the descending limb, leads to a

Matched Protein Synonyms: Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Description: substrates and then block the activation of downstream signaling pathways. Tyrosine kinase enzymes … ), and a small group of dual-specificity kinases (DSK) which can phosphorylate serine, threonine … families, including Abl, Ack, Csk, Fak, Fes/Fer, Jak, Src, Syk/Zap70, and Tec, with the addition of … . Tyrosine kinases help to send growth signals in cells, so blocking them stops the cell growing and … dividing. Cancer growth blockers can block one type of tyrosine kinase or more than one type. Tyrosine

Matched Proteins: Signal transducer and activator of transcription 5A … Son of sevenless homolog 1 … Bcl2-associated agonist of cell death

Matched Protein Synonyms: Mammalian target of rapamycin … Mechanistic target of rapamycin

Matched Description: channels, hyperpolarizing the cell and inhibiting the transmission of an action potential. The … multitude of neurologic and psychiatric conditions. Modulation of GABA signaling is the basis of many … , voltage-gated calcium channels open and calcium binds to synaptobrevin, which results in the fusion of … . GABA also has been found in varying low concentrations within other organ systems, though the significance and function of this are unclear. … neurotransmitter in the brain and a major inhibitory neurotransmitter in the spinal cord. It exerts its primary

Matched Protein Synonyms: GABA and glycine transporter